ASPRV1
Description
The ASPRV1 (aspartic peptidase retroviral like 1) is a protein-coding gene located on chromosome 2.
Retroviral aspartyl proteases, also known as retropepsins, are single-domain aspartyl proteases found in retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are typically part of a larger 'pol' or 'gag' polyprotein. They are homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins. Retropepsins are classified under MEROPS A2, clan AA, and are all endopeptidases. These enzymes function as homodimers, with each monomer contributing one catalytic aspartyl residue. Retroviral aspartyl protease is synthesized as part of the 'pol' polyprotein, which also includes reverse transcriptase, RNase H, and integrase. The 'pol' polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. However, not all retroviral aspartyl proteases generated from 'pol' are retropepsins in the strict sense. Spumapepsin from foamy virus is divergent enough to be classified in its own family, MEROPS A9.
ASPRV1 is also known as ADLI, MUNO, SASP, SASPase, Taps.
