ASIC4
Description
The ASIC4 (acid sensing ion channel subunit family member 4) is a protein-coding gene located on chromosome 2.
Acid-sensing ion channel 4 (ASIC4), also known as amiloride-sensitive cation channel 4 (ACCN4), is a protein encoded by the ASIC4 gene in humans. ASIC4 is one of five paralogous genes that encode proteins forming trimeric acid-sensing ion channels (ASICs) in mammals. The ASIC4 gene was first cloned in 2000. ASIC genes have splicing variants that encode different proteins called isoforms. These genes are primarily expressed in the central and peripheral nervous system. ASICs can form both homotrimeric (composed of three identical subunits) and heterotrimeric channels. ASIC4 is a member of the ASIC/ENaC superfamily of proteins. These proteins are amiloride-sensitive sodium channels containing intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop with many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (close to the N-terminus) and TM2 (close to the C-terminus). The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.
ASIC4 is also known as ACCN4, BNAC4.
