ASGR2
Description
The ASGR2 (asialoglycoprotein receptor 2) is a protein-coding gene located on chromosome 17.
ASGR2 is a protein involved in the removal of glycoproteins from circulation. It is a subunit of the asialoglycoprotein receptor, which binds to glycoproteins lacking sialic acid, exposing galactose residues. This receptor is mainly found on liver cells (hepatocytes) but also on some carcinoma cells, gallbladder, and stomach cells. ASGR2 forms dimers, trimers, and tetramers with the major subunit ASGR1 to facilitate substrate binding and endocytosis. ASGR2, along with ASGR1, plays a critical role in removing circulating glycoproteins and was first identified in 1968.
ASGR2 is also known as ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2.
Associated Diseases
- hyperlipidemia
- recurrent Neisseria infections due to factor D deficiency
- immunodeficiency 28
- mannose-binding lectin deficiency
- type II complement component 8 deficiency
- colorectal cancer
- immunodeficiency due to ficolin3 deficiency
- autosomal recessive severe congenital neutropenia due to JAGN1 deficiency
