ASCC3
Description
The ASCC3 (activating signal cointegrator 1 complex subunit 3) is a protein-coding gene located on chromosome 6.
Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a protein encoded by the ASCC3 gene in humans. It interacts with RELA, C-jun, and Serum response factor. ASCC3 has been implicated in DNA repair, particularly in the repair of alkylated DNA, and in ribosome quality control, where it helps to rescue stalled ribosomes.
ASCC3 is an ATPase involved in both DNA repair and rescue of stalled ribosomes. As a 3'-5' DNA helicase, it participates in the repair of alkylated DNA by promoting DNA unwinding to generate a single-stranded substrate required for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. ASCC3 also plays a role in activating the ribosome quality control (RQC) pathway, which degrades nascent peptide chains during problematic translation. It drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. ASCC3 is part of the ASC-1 complex, which enhances NF-kappa-B, SRF, and AP1 transactivation.
ASCC3 is also known as ASC1p200, HELIC1, MRT81, RNAH.
