ASCC2
Description
The ASCC2 (activating signal cointegrator 1 complex subunit 2) is a protein-coding gene located on chromosome 22.
Activating signal cointegrator 1 complex subunit 2 (ASCC2) is a protein encoded by the ASCC2 gene in humans. It is involved in DNA repair and rescue of stalled ribosomes. ASCC2 is a component of the ASCC complex and the ASC-1 complex. It interacts with various proteins, including ASCC3, ALKBH3, CSRP1, PRPF8, and ZCCHC4.
ASCC2 is a ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. It plays a role in DNA damage repair as a component of the ASCC complex, recruiting ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins. It is part of the ASC-1 complex, which enhances NF-kappa-B, SRF, and AP1 transactivation. ASCC2 is also involved in activating the ribosome quality control (RQC) pathway, degrading nascent peptide chains during problematic translation. It specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes.
ASCC2 is also known as ASC1p100, p100.
