ASB4
Description
The ASB4 (ankyrin repeat and SOCS box containing 4) is a protein-coding gene located on chromosome 7.
ASB4 likely functions as a substrate recognition component within an E3 ubiquitin ligase complex, specifically a SCF-like ECS complex. This complex is involved in tagging target proteins with ubiquitin, leading to their degradation by the proteasome. ASB4's role suggests it contributes to the regulation of various cellular processes through protein turnover. Additionally, it has been linked to the differentiation and maturation of vascular cells, possibly influenced by oxygen levels.
ASB4 is also known as ASB-4.
Associated Diseases
- familial idiopathic steroid-resistant nephrotic syndrome
- 46,XY complete gonadal dysgenesis
- focal segmental glomerulosclerosis 5
- glomerulopathy with fibronectin deposits 2
- primary membranoproliferative glomerulonephritis
- nail-patella-like renal disease
- adenine phosphoribosyltransferase deficiency
- Frasier syndrome
- cancer
