ASB17

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Description

The ASB17 (ankyrin repeat and SOCS box containing 17) is a protein-coding gene located on chromosome 1.

ASB17 is likely involved in the ubiquitination and degradation of specific target proteins. It does this by acting as a substrate recognition component within a larger protein complex called an ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex. This complex functions like a molecular tagging team, marking target proteins for destruction by attaching ubiquitin molecules.

ASB17 is also known as Asb-17.

Associated Diseases

• partial chromosome Y deletion
• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failure 25
• congenital bilateral absence of vas deferens
• spermatogenic failures 50
• spermatogenic failure 48
• spermatogenic failure 63
• spermatogenic failure 1
• spermatogenic failure 8
• spermatogenic failure 73
• spermatogenic failure 74
• spermatogenic failure 61
• spermatogenic failure 51
• spermatogenic failure, X-linked, 3
• spermatogenic failure 40
• spermatogenic failure 65
• spermatogenic failure 39
• spermatogenic failure 47
• spermatogenic failure 22
• spermatogenic failure 41