ASAP2
Description
The ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2) is a protein-coding gene located on chromosome 2.
ASAP2 activates the small GTPases ARF1, ARF5, and ARF6, which are involved in vesicle trafficking and cellular processes. It regulates the formation of post-Golgi vesicles, modulates constitutive secretion, and influences phagocytosis through interactions with Fc gamma receptor and ARF6. ASAP2 also modulates the recruitment of PXN (paxillin) to focal contacts and cell migration.
ASAP2 is also known as AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1.
