ARPC5
Description
The ARPC5 (actin related protein 2/3 complex subunit 5) is a protein-coding gene located on chromosome 1.
ARPC5 is a gene that encodes for one of the seven subunits of the Arp2/3 protein complex in humans. This complex is involved in controlling actin polymerization within cells and has been conserved throughout evolution. The exact function of the ARPC5 protein, known as the p16 subunit, remains to be fully determined. ARPC5 interacts with ARPC4.
ARPC5 is a component of the Arp2/3 complex, a multiprotein complex that facilitates actin polymerization in response to nucleation-promoting factors (NPFs). This complex plays a crucial role in the formation of branched actin networks within the cytoplasm, providing the driving force for cell motility. Beyond its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization within the nucleus, influencing gene transcription and the repair of damaged DNA. Specifically, the complex contributes to homologous recombination (HR) repair by promoting nuclear actin polymerization, which in turn facilitates the movement of double-strand breaks (DSBs).
ARPC5 is also known as ARC16, IMD113, dJ127C7.3, p16-Arc.
