ARPC4-TTLL3
Description
The ARPC4-TTLL3 (ARPC4-TTLL3 readthrough) is a protein-coding gene located on chromosome 3.
ARPC4-TTLL3 is a gene fusion resulting from a chromosomal translocation, specifically a t(10;11)(p13;q23) translocation. This fusion protein is associated with acute myeloid leukemia (AML). It is believed that the fusion protein disrupts normal cell function and contributes to uncontrolled cell growth, leading to the development of AML. Further research is needed to understand the exact mechanism by which the fusion protein promotes cancer development.
The ARPC4-TTLL3 fusion protein is a chimeric protein resulting from a chromosomal translocation, combining parts of the ARPC4 and TTLL3 genes. This fusion protein is associated with a specific type of cancer, known as acute myeloid leukemia (AML). It is believed that this fusion protein disrupts normal cell function and contributes to uncontrolled cell growth, leading to the development of AML. Further research is needed to fully understand the exact mechanism by which the ARPC4-TTLL3 fusion protein promotes cancer development.
ARPC4-TTLL3 is also known as ARC20, ARPC4, p20-ARC.
Associated Diseases
- X-linked retinal dysplasia
- choroidal dystrophy, central areolar, 1
- retinitis pigmentosa
- severe early-childhood-onset retinal dystrophy
- age related macular degeneration 4
- age related macular degeneration 7
- age related macular degeneration 11
- Leber congenital amaurosis
- hereditary mixed polyposis syndrome
- cleft lip-retinopathy syndrome
- X-linked retinoschisis
- AXIN2-related attenuated familial adenomatous polyposis
- Hirschsprung disease
- gastric adenocarcinoma and proximal polyposis of the stomach
- hyperplastic polyposis syndrome
- inflammatory bowel disease 30
- hypoparathyroidism, familial isolated, 2
- coloboma of optic nerve
- coloboma of macula
- Senior-Loken syndrome 7
