ARPC3
Description
The ARPC3 (actin related protein 2/3 complex subunit 3) is a protein-coding gene located on chromosome 12.
The ARPC3 gene produces a protein that is one of seven subunits of the Arp2/3 complex, which is involved in controlling actin polymerization in cells. The Arp2/3 complex is highly conserved across different species. The exact function of the ARPC3 protein (p21 subunit) is still being investigated.
The ARPC3 gene encodes a subunit of the Arp2/3 complex, a multiprotein complex that regulates actin polymerization. The Arp2/3 complex is activated by nucleation-promoting factors (NPFs) and mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Beyond its role in the cytoskeleton, the Arp2/3 complex also functions in the nucleus, where it promotes actin polymerization, contributing to gene transcription and DNA repair. Specifically, it aids in homologous recombination (HR) repair by promoting nuclear actin polymerization, which drives the movement of double-strand breaks (DSBs).
ARPC3 is also known as ARC21, p21-Arc.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- schizophrenia
- bipolar disorder
