ARPC2
Description
The ARPC2 (actin related protein 2/3 complex subunit 2) is a protein-coding gene located on chromosome 2.
ARPC2, or Actin-related protein 2/3 complex subunit 2, is a human gene encoding a protein subunit of the Arp2/3 complex. This complex plays a crucial role in regulating actin polymerization within cells, a process essential for various cellular functions, including cell motility. The specific function of the ARPC2 protein, the p34 subunit, is still under investigation. There are two known alternatively spliced variants of this gene, with additional variants yet to be fully characterized. ARPC2 has been shown to interact with Cortactin, suggesting its involvement in cell signaling pathways.
ARPC2 is a protein subunit of the Arp2/3 complex, which is essential for actin polymerization. The Arp2/3 complex is activated by nucleation-promoting factors (NPFs) and forms branched actin networks in the cytoplasm, driving cell motility. This protein interacts with the mother actin filament and contributes to the overall structure and function of the complex. Beyond its role in the cytoplasm, the Arp2/3 complex also influences nuclear actin polymerization, which regulates gene transcription and DNA repair. In response to DNA damage, the complex promotes homologous recombination (HR) repair by driving the movement of double-strand breaks (DSBs).
ARPC2 is also known as ARC34, PNAS-139, PRO2446, p34-Arc.
