ARNTL
Title: ARNTL: The Master Regulator of Circadian Rhythms and Beyond
Description:
ARNTL, also known as BMAL1, is a crucial transcription factor that plays a central role in regulating circadian rhythms—the body's natural 24-hour cycle that influences various physiological and behavioral processes, such as sleep-wake cycles, hormone release, and metabolism.
Associated Diseases:
Dysregulation of ARNTL and its downstream pathways have been linked to several diseases, including:
- Sleep Disorders: Insomnia, delayed sleep phase syndrome (DSPS)
- Cardiovascular Disease: Hypertension, stroke
- Metabolic Disorders: Obesity, type 2 diabetes
- Cancer: Colon, breast, lung
- Neurodegenerative Disorders: Alzheimer's disease, Parkinson's disease
Did you Know ?
Studies have shown that individuals with genetic variations in ARNTL tend to have disrupted circadian rhythms and an increased risk of developing certain diseases, such as obesity and metabolic disorders.
