ARNT
Description
The ARNT (aryl hydrocarbon receptor nuclear translocator) is a protein-coding gene located on chromosome 1.
ARNT is a protein that plays a critical role in cellular response to environmental cues, particularly in the regulation of gene expression related to hypoxia and xenobiotic compounds. It is a key component of the AHR signaling pathway and functions in the regulation of cellular responses to hypoxia by interacting with HIF1A, EPAS1, NPAS1, and NPAS3.
ARNT is essential for the activity of the AHR (aryl hydrocarbon receptor). Upon ligand binding, AHR moves into the nucleus where it forms a complex with ARNT. This complex then activates transcription by binding to xenobiotic response elements (XREs). ARNT is not necessary for the AHR to move from the cytoplasm to the nucleus after ligand binding. The AHR/ARNT complex plays a role in regulating a range of biological processes including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. The AHR/ARNT complex binds to the hypoxia response element (HRE) in target gene promoters and regulates the adaptive response to hypoxia. The AHR/ARNT complex also binds to the dioxin response element (DRE) in target gene promoters and activates transcription.
ARNT is also known as ARNT1, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2.
Associated Diseases
- carcinoma of liver and intrahepatic biliary tract
- hemangioblastoma
- lysosomal storage disease
- Alzheimer disease
- multiple sclerosis
- Parkinson disease
- gastrointestinal stromal tumor
