ARMCX3
Description
The ARMCX3 (armadillo repeat containing X-linked 3) is a protein-coding gene located on chromosome X.
ARMCX3 is a protein encoded by the ARMCX3 gene in humans. It belongs to the ALEX family of proteins, which might be involved in suppressing tumor growth. The protein contains a potential transmembrane domain at its beginning and a single Armadillo repeat. Armadillo repeats are found in other proteins involved in development, tissue maintenance, and cancer development. This gene is located near other family members on the X chromosome. Three different forms of the gene's transcript are known, all producing the same protein.
ARMCX3 plays a vital role in regulating the movement and clustering of mitochondria within the axons of living neurons. It acts as a bridge, connecting mitochondria to the TRAK2-kinesin motor complex through its interactions with Miro and TRAK2. The breakdown of ARMCX3 protein is influenced by PCK, which promotes degradation, and WNT1, which inhibits it, ultimately impacting mitochondrial distribution and dynamics within the neuron. Moreover, ARMCX3 enhances the activity of SOX10 in activating the genes for the alpha-3 and beta-4 subunits of the neuronal acetylcholine receptor.
ARMCX3 is also known as ALEX3, GASP6, dJ545K15.2.
Associated Diseases
- osteoporosis-pseudoglioma syndrome
- very long chain acyl-CoA dehydrogenase deficiency
- cancer
- type 2 diabetes mellitus
