ARL6IP5
Description
The ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5) is a protein-coding gene located on chromosome 3.
ARL6IP5 is a protein encoded by the ARL6IP5 gene in humans. Its expression is influenced by vitamin A and the protein may be associated with the cytoskeleton. A similar protein in rats may play a role in cell differentiation. The rat protein binds to and inhibits the glutamate transporter EAAC1, and its expression is increased by retinoic acid, which leads to a reduction in glutamate transport by EAAC1. Disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress, and improved performance in motor/spatial learning and memory tests compared to wild-type mice. ARL6IP5 interacts with SLC1A1.
ARL6IP5 is also known as DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx.
