ARL5A

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Description

The ARL5A (ADP ribosylation factor like GTPase 5A) is a protein-coding gene located on chromosome 2.

ARL5A is a human gene that encodes a protein called ADP-ribosylation factor-like protein 5A. This protein is involved in various cellular processes, including vesicle trafficking and signal transduction. ARL5A is a member of the ADP-ribosylation factor (ARF) family of proteins, which are known to regulate membrane trafficking by activating phospholipase D (PLD) and other enzymes. However, unlike other ARF proteins, ARL5A does not possess ADP-ribosylation enhancing activity. This suggests that ARL5A may play a unique role in cellular processes compared to other ARF family members.

ARL5A does not enhance ADP-ribosylation.

ARL5A is also known as ARFLP5, ARL5.

Associated Diseases

• familial atrial fibrillation
• Brugada syndrome
• familial sick sinus syndrome
• sinoatrial node dysfunction and deafness
• long QT syndrome 9
• long QT syndrome 5
• ventricular fibrillation, paroxysmal familial, type 1
• arrhythmogenic right ventricular dysplasia 1
• Brugada syndrome 9
• sick sinus syndrome 1
• cardiomyopathy, dilated, 2I
• atrial fibrillation, familial, 9
• Brugada syndrome 3