ARHGAP32
Description
The ARHGAP32 (Rho GTPase activating protein 32) is a protein-coding gene located on chromosome 11.
ARHGAP32 acts as a GTPase-activating protein (GAP), promoting the hydrolysis of GTP on the small GTPases RHOA, CDC42, and RAC1. This protein may play a role in the differentiation of neuronal cells during neurite extension, and it is involved in actin reorganization within dendritic spines, a process dependent on NMDA receptor activity. Additionally, ARHGAP32 might mediate communication between Ras- and Rho-regulated signaling pathways, impacting cell growth regulation. Isoform 2 exhibits higher GAP activity compared to other isoforms.
ARHGAP32 is also known as GC-GAP, GRIT, PX-RICS, RICS, p200RhoGAP, p250GAP.
Associated Diseases
- behavioral variant of frontotemporal dementia
- childhood disintegrative disorder
- Huntington disease-like syndrome due to C9ORF72 expansions
- 15q11q13 microduplication syndrome
- developmental and epileptic encephalopathy, 9
- cortical dysplasia-focal epilepsy syndrome
- intellectual developmental disorder with paroxysmal dyskinesia or seizures
- early-onset autosomal dominant Alzheimer disease
- amyotrophic lateral sclerosis
