ARHGAP26
Description
The ARHGAP26 (Rho GTPase activating protein 26) is a protein-coding gene located on chromosome 5.
ARHGAP26, also known as GRAF1 (GTPase Regulator Associated with Focal Adhesion Kinase), is a protein encoded by the ARHGAP26 gene in humans. It plays a key role in the CLIC/GEEC endocytic pathway, where it sculpts endocytic membranes into tubules and vesicles, facilitating the uptake of extracellular fluid, GPI-linked proteins, and certain bacterial exotoxins. ARHGAP26 interacts with dynamin, although its role in this pathway is debated. Several members of the GRAF family, including GRAF2, GRAF3, and oligophrenin, likely share similar functions in clathrin-independent endocytosis. Mutations in GRAF1 and oligophrenin have been linked to human diseases like leukemia and mental retardation, respectively. Recently, autoantibodies targeting ARHGAP26 have been implicated in autoimmune cerebellar ataxia. ARHGAP26 has been shown to interact with PKN3.
ARHGAP26 acts as a GTPase-activating protein for the small GTPases RHOA and CDC42.
ARHGAP26 is also known as GRAF, GRAF1, OPHN1L, OPHN1L1.
