ARHGAP22
Description
The ARHGAP22 (Rho GTPase activating protein 22) is a protein-coding gene located on chromosome 10.
ARHGAP22 is a Rho GTPase-activating protein that plays a crucial role in regulating angiogenesis, the formation of new blood vessels. Specifically, it acts as a GTPase activator for RAC1, converting it to an inactive GDP-bound state, which inhibits the formation of lamellipodia, structures essential for cell migration. Moreover, ARHGAP22 might also participate in transcription regulation through its interaction with VEZF1, potentially influencing the activity of the endothelin-1 (EDN1) promoter.
ARHGAP22 is also known as RhoGAP2, RhoGap22.
Associated Diseases
- systemic lupus erythematosus
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- microcytic anemia with liver iron overload
- hypoparathyroidism, familial isolated, 2
- 22q11.2 deletion syndrome
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- dominant beta-thalassemia
- cholesterol-ester transfer protein deficiency
- delta-beta-thalassemia
- IRIDA syndrome
