ARHGAP18
Description
The ARHGAP18 (Rho GTPase activating protein 18) is a protein-coding gene located on chromosome 6.
ARHGAP18, also known as MacGAP and bA307O14.2, is a protein encoded by the ARHGAP18 gene in humans. This protein belongs to a family of Rho GTPase-activating proteins that modulate cell signaling.
ARHGAP18, also known as MacGAP or Rho-type GTPase-activating protein 18, functions as a Rho GTPase-activating protein that inhibits Rho activity. This inhibition suppresses F-actin polymerization, which is crucial for maintaining cell shape, spreading, and migration. ARHGAP18 plays a critical role in regulating cortical actomyosin network formation, thereby influencing tissue tension and 3D tissue shape. It also acts downstream of YAP1, inhibiting actin polymerization and consequently reducing YAP1's nuclear localization. These actions ultimately contribute to regulating cell shape, spreading, and migration. (PubMed:21865595, PubMed:25778702)
ARHGAP18 is also known as MacGAP, SENEX, bA307O14.2.
