ARHGAP10
Description
The ARHGAP10 (Rho GTPase activating protein 10) is a protein-coding gene located on chromosome 4.
ARHGAP10 is a protein that regulates the activity of Rho GTPases, a family of small GTPases involved in various cellular processes. It acts as a GTPase-activating protein (GAP), converting active GTP-bound Rho GTPases to their inactive GDP-bound form. This inactivation suppresses Rho GTPase-mediated cellular processes. ARHGAP10 also interacts with other proteins, including PTKB2, PAK2, MICAL1, and WDR44, influencing cell death, endosomal tubule extension, and protein export.
ARHGAP10 is a GTPase-activating protein (GAP) that inactivates Rho GTPases by catalyzing the conversion of their active GTP-bound form to the inactive GDP-bound form. This activity suppresses various Rho GTPase-mediated cellular processes, including cytoskeletal organization. ARHGAP10 also inactivates Cdc42, another small GTPase, and plays a critical role in PTKB2-mediated regulation of cytoskeletal organization. ARHGAP10 inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and relocates it from the nucleus to the perinuclear region. This stabilization of PAK-2p34 enhances cell death. ARHGAP10 interacts with MICAL1 on the endosomal membrane, promoting Rab8-Rab10-dependent tubule extension. After dissociating from MICAL1, ARHGAP10 recruits WDR44, connecting the endoplasmic reticulum (ER) with the endosomal tubule and participating in the export of a subset of neosynthesized proteins.
ARHGAP10 is also known as GRAF2, PS-GAP, PSGAP.
