ARFIP2
Description
The ARFIP2 (ADP ribosylation factor interacting protein 2) is a protein-coding gene located on chromosome 11.
Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene. ARFIP2 has been shown to interact with Arf6, ARF3, ARF5 and RAC1.
ARFIP2 plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. It may have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. ARFIP2 is also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. It is involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, ARFIP2 plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.
ARFIP2 is also known as POR1.
Associated Diseases
- familial idiopathic steroid-resistant nephrotic syndrome
- proteinuria, chronic benign
- focal segmental glomerulosclerosis 7
- nephrotic syndrome 16
- Dent disease
- nail-patella-like renal disease
- focal segmental glomerulosclerosis 5
- familial steroid-resistant nephrotic syndrome with sensorineural deafness
- lipoprotein glomerulopathy
- glomerulopathy with fibronectin deposits 2
- congenital nephrotic syndrome, Finnish type
- hyperprolinemia type 1
- type 2 diabetes mellitus
- breast cancer
