ARFIP1
Description
The ARFIP1 (ADP ribosylation factor interacting protein 1) is a protein-coding gene located on chromosome 4.
Arfaptin-1 is a protein encoded by the ARFIP1 gene in humans. It interacts with ARF3.
ARFIP1 plays a critical role in the formation of secretory granules at the trans-Golgi network. It binds to ARF-GTP at the neck of a growing secretory granule precursor, forming a protective scaffold. This binding allows the precursor to accumulate cargo. Once the precursor is fully loaded, PRKD1 phosphorylates ARFIP1, releasing it from ARFs. This release triggers ARF-mediated fission, leading to the formation of mature secretory granules. This process is essential for proper secretory granule formation in pancreatic beta cells.
ARFIP1 is also known as HSU52521.
