ARFGEF1
Description
The ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1) is a protein-coding gene located on chromosome 8.
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.
== Function == ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.
== Interactions == ARFGEF1 has been shown to interact with FKBP2, ARFGEF2 and PRKAR1A.
== References ==
== External links == Human ARFGEF1 genome location and ARFGEF1 gene details page in the UCSC Genome Browser.
ARFGEF1 promotes guanine-nucleotide exchange on ARF1 and ARF3, leading to their activation by replacing GDP with GTP. This activity is crucial for vesicular trafficking and the maintenance of Golgi structure, potentially independent of its GEF activity. ARFGEF1 is involved in the maturation of integrin beta-1 within the Golgi and contributes to establishing and maintaining cell polarity during directed cell movement, as seen in wound healing. It has been proposed to act as an A kinase-anchoring protein (AKAP), potentially mediating crosstalk between Arf and PKA pathways. ARFGEF1 also inhibits the GAP activity of MYO9B, likely through competitive RhoA binding. The function of ARFGEF1 in the nucleus remains to be determined.
ARFGEF1 is also known as ARFGEP1, BIG1, DEDISB, P200.
