ARFGAP3
Description
The ARFGAP3 (ADP ribosylation factor GTPase activating protein 3) is a protein-coding gene located on chromosome 22.
ARFGAP3 is a protein encoded by the human ARFGAP3 gene. It acts as a GTPase-activating protein (GAP) associated with the Golgi apparatus and interacts with ADP-ribosylation factor 1 (ARF1). ARFGAP3 promotes the hydrolysis of GTP bound to ARF1, which is essential for the detachment of coat proteins from Golgi-derived membranes and vesicles. This detachment is a prerequisite for the fusion of these vesicles with their target compartments. Notably, the activity of ARFGAP3 is influenced by phospholipids. It's important to note that this gene was previously known as ARFGAP1, but that name now refers to a distinct, albeit related, gene.
ARFGAP3 is a GTPase-activating protein (GAP) that specifically targets ADP-ribosylation factor 1 (ARF1). By hydrolyzing GTP bound to ARF1, ARFGAP3 promotes the dissociation of coatomer proteins from Golgi-derived membranes. This process is crucial for facilitating the fusion of these vesicles with their intended target compartments.
ARFGAP3 is also known as ARFGAP1.
