AREL1

Description

The AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1) is a protein-coding gene located on chromosome 14.

AREL1 is an E3 ubiquitin ligase that catalyzes the formation of 'Lys-11' or 'Lys-33' linked polyubiquitin chains, with a preference for 'Lys-33' linkages. It accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and directly transfers it to target substrates. AREL1 has been shown to ubiquitinate SEPTIN4, DIABLO/SMAC, and HTRA2 in vitro. It also modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome. These findings are supported by multiple studies, including those published in PubMed with IDs 23479728, 25752577, and 31578312.

AREL1 is also known as FIEL1, KIAA0317.

Associated Diseases

• major depressive disorder
• bipolar disorder
• Parkinson disease
• schizophrenia 15
• Phelan-McDermid syndrome
• glycogen storage disorder due to hepatic glycogen synthase deficiency