ARAF
Description
The ARAF gene provides instructions for making a protein called ARAF, a key component of the RAS/RAF/MEK/ERK signaling pathway, which plays a vital role in controlling cell growth, proliferation, and survival. This pathway is activated by a variety of external stimuli, including growth factors and hormones. ARAF acts as a molecular switch, activating downstream proteins that ultimately influence gene expression and cellular behavior. Dysregulation of ARAF signaling is implicated in various diseases, particularly cancers.
Associated Diseases
- Cancer (particularly melanoma, colorectal cancer, and lung cancer)
- Neurofibromatosis type 1 (NF1)
- Noonan syndrome
- Cardio-facio-cutaneous syndrome (CFC syndrome)
Did you know?
Mutations in the ARAF gene are associated with a rare genetic disorder called cardio-facio-cutaneous syndrome, which is characterized by heart defects, facial abnormalities, and skin problems.
