AQP9

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Description

The AQP9 (aquaporin 9) is a protein-coding gene located on chromosome 15.

Aquaporin-9 (AQP-9) is a protein encoded by the AQP9 gene in humans. It belongs to the aquaporin/major intrinsic protein family, which are water-selective membrane channels. AQP-9 shares greater sequence similarity with AQP3 and AQP7, suggesting they may form a subfamily. AQP-9 allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability. Its role in providing glycerol permeability is debated. AQP-9 may also have a role in specialized leukocyte functions, such as immunological response and bactericidal activity.

AQP9 forms a water channel with broad specificity, permeable to glycerol and urea. It facilitates the passage of a wide range of small, uncharged solutes including carbamides, polyols, purines, and pyrimidines.

AQP9 is also known as AQP-9, HsT17287, SSC1, T17287.