APOO
Description
The APOO (apolipoprotein O) is a protein-coding gene located on chromosome X.
APOO, also known as MIC26, is a component of the MICOS complex, a large protein complex found in the inner membrane of mitochondria. It plays a vital role in the formation of crista junctions, which are essential for proper mitochondrial function. This complex also helps maintain the architecture of the inner membrane and creates contact sites with the outer membrane. APOO‘s role in crista junction formation and mitochondrial function is crucial for the cell‘s overall energy production and metabolism. Additionally, APOO can contribute to cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. It also facilitates cholesterol efflux from macrophage cells and is detected in HDL, LDL, and VLDL. APOO is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, initially as a VLDL-associated protein, and subsequently transferred to HDL.
APOO is also known as FAM121B, MIC26, MICOS26, Mic23, My025.
