APOM

Description

The APOM (apolipoprotein M) is a protein-coding gene located on chromosome 6.

Apolipoprotein M is a protein belonging to the lipocalin family, encoded by the APOM gene in humans. It associates with high-density lipoproteins, and to a lesser extent, low-density lipoproteins and triglyceride-rich lipoproteins. Secreted through the plasma membrane, Apo-M remains membrane-bound and participates in lipid transport. Two transcript variants have been identified for this gene, but only one has been fully characterized. It lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide. The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.

Apolipoprotein M (Apo-M) likely plays a role in lipid transport. It has the ability to bind various molecules including sphingosine-1-phosphate, myristic acid, palmitic acid, stearic acid, retinol, all-trans-retinoic acid, and 9-cis-retinoic acid.

APOM is also known as G3a, HSPC336, NG20, apo-M.