APOL2
Description
The APOL2 gene, residing on chromosome 22, codes for a protein that plays a crucial role in defending against trypanosomes, parasitic protozoa causing African trypanosomiasis. This protein, known as apolipoprotein L2, exhibits a remarkable ability to permeabilize the parasite‘s membrane, effectively eliminating the threat. While this function is vital for protection against disease, certain genetic variants within APOL2 have been linked to an increased risk of kidney disease, primarily in individuals of African descent. Understanding the nuances of this gene‘s influence on both immunity and disease susceptibility is paramount for advancing preventative strategies and personalized therapies.
Associated Diseases
- Focal Segmental Glomerulosclerosis (FSGS)
- Hypertensive Nephropathy
- End-Stage Renal Disease (ESRD)
- African Trypanosomiasis (Sleeping Sickness)
Did you know?
The protective role of APOL2 against trypanosomes is a testament to the evolutionary pressure exerted by this disease in certain populations.
