APOF
Description
The APOE gene, located on chromosome 19, encodes the apolipoprotein E protein, a crucial component of lipoproteins that transport cholesterol throughout the body. APOE plays a vital role in lipid metabolism, brain function, and immune responses. There are three common alleles of the APOE gene: APOE2, APOE3, and APOE4, each associated with different levels of cholesterol transport and disease risk. Understanding the complexities of APOE function and its genetic variations provides valuable insights into cardiovascular health, Alzheimer‘s disease, and other neurological disorders.
Associated Diseases
- Alzheimer‘s disease
- Cardiovascular disease (atherosclerosis, coronary artery disease)
- Type 3 hyperlipoproteinemia
- Peripheral artery disease
- Stroke
- Cognitive decline
- Dementia
Did you know?
The APOE4 allele, while increasing the risk of Alzheimer‘s disease, may also offer some protection against other neurological disorders like Parkinson‘s disease.
