APOC4-APOC2
Description
The APOC4-APOC2 gene cluster, located on chromosome 19, plays a pivotal role in lipid metabolism. It encodes two key proteins: apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2). APOC4 acts as a co-factor in lipoprotein lipase (LPL) activity, influencing triglyceride metabolism. APOC2, on the other hand, is essential for the activation of LPL, promoting the breakdown of triglycerides into fatty acids. Variations in this gene cluster have been linked to altered lipid profiles and an increased risk of cardiovascular diseases.
Associated Diseases
Did you know?
The APOC4-APOC2 gene cluster has a high degree of polymorphism, contributing to the wide variation in lipid profiles observed in the population.
