APOBEC3A_B
Description
APOBEC3A and APOBEC3B are two members of the APOBEC3 family of cytidine deaminases. These enzymes play crucial roles in the innate immune system by targeting and deaminating cytidine bases in DNA, particularly in retroviruses like HIV. This deamination process introduces mutations, ultimately hindering the replication of these viruses. However, APOBEC3A and APOBEC3B have also been implicated in various human diseases, including cancer, autoimmune disorders, and neurodevelopmental disorders.
Associated Diseases
- Cancer (e.g., breast cancer, lung cancer, bladder cancer)
- Autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis)
- Neurodevelopmental disorders (e.g., autism spectrum disorder)
Did you know?
APOBEC3A and APOBEC3B are highly expressed in immune cells, particularly in B cells and macrophages.
