APOBEC3A
Description
APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A) is a gene that encodes a protein involved in the innate immune system‘s defense against retroviruses and other foreign genetic elements. APOBEC3A primarily functions as a cytidine deaminase, catalyzing the conversion of cytosine to uracil in DNA. This deamination activity targets viral DNA, disrupting its replication and hindering its ability to spread within the host. While APOBEC3A plays a vital role in antiviral defense, its activity is tightly regulated to avoid damaging the host‘s own genome. Dysregulation of APOBEC3A can contribute to the development of certain cancers and autoimmune disorders.
Associated Diseases
- HIV infection
- Hepatitis B virus infection
- Cancer (e.g., breast cancer, lung cancer, melanoma)
- Autoimmune diseases (e.g., systemic lupus erythematosus)
Did you know?
APOBEC3A is highly expressed in certain immune cells, particularly those involved in antiviral defense, such as lymphocytes and macrophages.
