APIP
Description
The APIP (APAF1 interacting protein) is a protein-coding gene located on chromosome 11.
APAF1-interacting protein (APIP) is a human protein encoded by the APIP gene. It functions as an enzyme with Methylthioribulose 1-phosphate dehydratase activity, playing a role in the methionine salvage pathway. APIP deficiency has been linked to cell death and cancer. APIP interacts with APAF1.
APIP catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) to 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). This enzyme is part of the methionine salvage pathway, a crucial pathway involved in various cellular processes, including cancer, apoptosis, microbial proliferation, and inflammation. APIP may play a role in inhibiting the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway, and the cytochrome c-dependent and APAF1-mediated cell death. APIP exists as a homotetramer.
APIP is also known as APIP2, CGI-29, CGI29, MMRP19, hAPIP.
Associated Diseases
- type 2 diabetes mellitus
- cystic fibrosis
- pyruvate dehydrogenase E3-binding protein deficiency
- systemic lupus erythematosus
- plasma fibronectin deficiency
- isolated asymptomatic elevation of creatine phosphokinase
- congenital lethal erythroderma
