APEX1
Description
APEX1, also known as AP endonuclease 1, is a crucial enzyme involved in the base excision repair (BER) pathway. This pathway is essential for removing damaged or modified bases from DNA, preventing mutations and maintaining genomic stability. APEX1 specifically recognizes and cleaves the DNA backbone at abasic sites, which are gaps left behind after damaged bases are removed. This activity creates a 5‘-deoxyribose phosphate (dRP) group, making the site accessible for further repair by other BER enzymes. APEX1‘s role in DNA repair is vital for protecting cells from various insults, including oxidative stress, UV radiation, and environmental toxins.
Associated Diseases
Did you know?
APEX1 is highly conserved across species, indicating its importance for cellular survival.
