AP5M1
Description
The AP5M1 (adaptor related protein complex 5 subunit mu 1) is a protein-coding gene located on chromosome 14.
AP5M1, also known as MUDENG (MuD), is a highly conserved protein encoded by the AP5M1 gene. It was discovered while searching for genes that promote cell death in Fas-mediated apoptosis. MuD is the medium-sized subunit of the AP5 adaptor complex and is expressed throughout the body. It is found within both the mitochondria and the endoplasmic reticulum (ER) of cells. MuD has been shown to induce apoptosis but may also play an anti-apoptotic role in apoptosis mediated by TRAIL. MuD has a tertiary structure with three domains, with amino acids 197 through 417 forming an adaptin domain found in AP μ subunits. The adaptin domain contains two aspartic acids, D276 and D290, which serve as binding sites for caspase-3. However, the overall function of MuD remains unclear.
AP5M1 is also known as C14orf108, MUDENG, Mu5, MuD.
