AP2A2
Description
The AP2A2 (adaptor related protein complex 2 subunit alpha 2) is a protein-coding gene located on chromosome 11.
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.
== Interactions == AP2A2 has been shown to interact with EPN1 and SHC1.
== References ==
== Further reading ==
== External links == Human AP2A2 genome location and AP2A2 gene details page in the UCSC Genome Browser.
AP-2 is a protein complex involved in clathrin-dependent endocytosis, a process where cargo proteins are packaged into vesicles surrounded by clathrin. These clathrin-coated vesicles (CCVs) are essential for transporting cargo to the early endosome. AP-2 acts as a major clathrin adaptor, binding to both the clathrin lattice and membrane components to facilitate CCV formation. It also serves as a cargo receptor, selectively sorting membrane proteins involved in receptor-mediated endocytosis. Furthermore, AP-2 plays a role in recycling synaptic vesicle membranes and recognizing endocytosis signal motifs within transmembrane cargo molecules. It may also contribute to post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. In hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 during long-term potentiation. The alpha subunit of AP-2 binds to polyphosphoinositide-containing lipids, anchoring AP-2 to the membrane. Its C-terminal appendage domain acts as a scaffolding platform for other endocytic accessory proteins. The alpha and sigma subunits of AP-2 are believed to recognize specific endocytosis signal motifs.
AP2A2 is also known as ADTAB, CLAPA2, HIP-9, HIP9, HYPJ.
Associated Diseases
- endometrial cancer
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- thyroid hormone metabolism, abnormal, 2
- sitosterolemia
- homozygous familial hypercholesterolemia
- hypercholesterolemia, autosomal dominant, 3
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- familial apolipoprotein C-II deficiency
- hemochromatosis type 5
