AP1M2
Description
The AP1M2 (adaptor related protein complex 1 subunit mu 2) is a protein-coding gene located on chromosome 19.
AP-1 complex subunit mu-2 is a protein encoded by the AP1M2 gene in humans. It is a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein can interact with tyrosine-based sorting signals. AP1M2 has been shown to interact with AP2B1.
AP1M2 is a subunit of the clathrin-associated adaptor protein complex 1 (AP-1). It plays a crucial role in protein sorting within the trans-Golgi network (TGN) and endosomes. AP-1 complexes facilitate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
AP1M2 is also known as AP1-mu2, HSMU1B, MU-1B, MU1B, mu2.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- cancer
- congenital diarrhea 7 with exudative enteropathy
- chylomicron retention disease
- atresia of small intestine
- bile acid malabsorption, primary, 1
- hereditary mixed polyposis syndrome
