ANPEP
Description
The ANPEP gene encodes aminopeptidase N (APN), a membrane-bound enzyme with diverse roles in various physiological processes. APN is involved in the breakdown of proteins, peptide hormones, and neuropeptides, contributing to digestion, immune regulation, and cell signaling. It plays a crucial role in the processing and activation of chemokines, cytokines, and growth factors, influencing inflammation, angiogenesis, and tumor growth. APN‘s activity is tightly regulated, with its expression and function influenced by various factors, including hormones, cytokines, and cellular stress. Mutations in the ANPEP gene can lead to a range of genetic disorders.
Associated Diseases
- Hypophosphatasia
- Canavan disease
- Congenital disorder of glycosylation (CDG) type Ia
- X-linked agammaglobulinemia (XLA)
- Amyotrophic lateral sclerosis (ALS)
- Cancer (various types)
- Inflammatory bowel disease (IBD)
- Alzheimer‘s disease
Did you know?
APN is also known as CD13, a marker for certain types of cancer cells.
