ANP32D
Description
ANP32D, also known as the Acidic Nuclear Phosphoprotein 32 kDa, is a gene encoding a protein involved in various cellular processes, primarily protein degradation and the response to cellular stress. ANP32D plays a crucial role in the ubiquitin-proteasome system, a major pathway for protein degradation within cells. This protein interacts with components of the proteasome, facilitating the breakdown of misfolded or damaged proteins, thus maintaining cellular homeostasis. Additionally, ANP32D contributes to the unfolded protein response (UPR), a cellular mechanism triggered by the accumulation of misfolded proteins in the endoplasmic reticulum (ER). The UPR aims to alleviate stress in the ER by inducing protein folding chaperones and inhibiting protein translation. ANP32D‘s involvement in both protein degradation and stress response pathways underscores its significance in maintaining cellular health and function.
Associated Diseases
- Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Cancer (e.g., breast cancer, lung cancer)
- Inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
- Metabolic disorders (e.g., diabetes, obesity)
Did you know?
ANP32D has been shown to be involved in the regulation of autophagy, a process where cells degrade and recycle their own components.
