ANP32A
Description
The ANP32A (acidic nuclear phosphoprotein 32 family member A) is a protein-coding gene located on chromosome 15.
Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. It is one of the targets of an oncomiR, MIRN21. ANP32A has been shown to interact with MAP1B, TAF1A and Protein SET. See also: ANP32B, ANP32C, ANP32D, ANP32E
ANP32A is a multifunctional protein involved in regulating various cellular processes, including tumor suppression, apoptosis, cell cycle progression, and transcription. It promotes apoptosis by activating caspase-9 and facilitating apoptosome formation. ANP32A is a component of the INHAT (inhibitor of histone acetyltransferases) complex, where it modulates histone acetylation and transcription. It inhibits the histone acetyltransferase activity of EP300/CREBBP by histone masking, preferentially binding to unmodified histone H3 and hindering its acetylation and phosphorylation, ultimately inhibiting cell growth. Additionally, ANP32A regulates mRNA nuclear-to-cytoplasmic translocation and stability by associating with ELAVL1 (Hu-antigen R). It contributes to E4F1-mediated transcriptional repression and inhibits protein phosphatase 2A.
ANP32A is also known as C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32.
