ANKS1A
Description
The ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) is a protein-coding gene located on chromosome 6.
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein encoded by the ANKS1A gene on chromosome 6 in humans. It is expressed in various tissues and cell types. ODIN regulates the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways. As a Src family kinase target, ODIN is implicated in cancer development. The ANKS1A gene is associated with an increased risk of coronary artery disease. The ANKS1A gene is located on chromosome 6 at the band 6p21.31 and includes 29 exons. It produces 2 isoforms through alternative splicing. ODIN is a member of the ankyrin repeat and sterile alpha motif domain-containing (ANKS) family. It contains 6 ankyrin repeats, 1 phosphotyrosine binding (PTD) domain, and 2 tandem sterile alpha motif (SAM) domains. The first SAM domain interacts with the SAM domain of the EphA2 receptor by adopting a mid-loop/end-helix conformation, potentially regulating EphA2 endocytosis. ODIN is widely expressed in tissues including the heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
ANKS1A is also known as ANKS1.
