ANKRD31

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Description

The ANKRD31 (ankyrin repeat domain 31) is a protein-coding gene located on chromosome 5.

ANKRD31 is a protein encoded by the ANKRD31 gene in humans.

ANKRD31 is essential for the creation of DNA double-strand breaks (DSBs) during meiotic recombination. It acts as a scaffold, organizing the assembly of the recombinosome (a protein complex involved in recombination) at specific locations within the genome. By controlling the timing and placement of this process, ANKRD31 regulates the rate and pattern of DSB formation. Additionally, it plays a crucial role in recombination within the pseudoautosomal regions of sex chromosomes, areas where the X and Y chromosomes share genes.

ANKRD31 is also known as -.

Associated Diseases

• Alzheimer disease
• partial chromosome Y deletion
• spermatogenic failure 63
• spermatogenic failure 65
• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failure, X-linked, 3
• spermatogenic failure 25
• spermatogenic failure 40
• spermatogenic failure 72
• spermatogenic failure 39
• spermatogenic failure 47
• spermatogenic failure 46
• spermatogenic failure 27
• spermatogenic failure 18
• spermatogenic failures 50
• spermatogenic failure 10