ANAPC4
Description
The ANAPC4 (anaphase promoting complex subunit 4) is a protein-coding gene located on chromosome 4.
Anaphase-promoting complex subunit 4 (ANAPC4) is an enzyme encoded by the ANAPC4 gene in humans. It is a component of the anaphase-promoting complex (APC), also known as the cyclosome, which plays a critical role in the transition from metaphase to anaphase during cell division. The APC ubiquitinates specific substrates, such as mitotic cyclins and anaphase inhibitors, leading to their degradation by the 26S proteasome. The vertebrate APC contains eight subunits, and its composition is highly conserved across various organisms. The exact function of ANAPC4 remains unknown. ANAPC4 interacts with several other proteins, including ANAPC1, ANAPC5, CDC27, and ANAPC7.
ANAPC4 is a subunit of the anaphase-promoting complex/cyclosome (APC/C), a crucial cell cycle regulator. APC/C acts as an E3 ubiquitin ligase, controlling transitions through mitosis and the G1 phase of the cell cycle. Its primary function is to ubiquitinate target proteins, leading to their degradation. APC/C predominantly mediates the formation of 'Lys-11'-linked polyubiquitin chains, but also participates in the formation of 'Lys-48'- and 'Lys-63'-linked chains.
ANAPC4 is also known as APC4.
