ANAPC15

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Description

The ANAPC15 (anaphase promoting complex subunit 15) is a protein-coding gene located on chromosome 11.

ANAPC15 is a component of the anaphase-promoting complex/cyclosome (APC/C), a crucial enzyme complex that regulates the cell cycle. It plays a vital role in the release of the mitotic checkpoint complex (MCC) from the APC/C, which is essential for the proper progression through mitosis. While not directly involved in APC/C activity, ANAPC15 facilitates the turnover of CDC20 and MCC on the APC/C, thereby contributing to the spindle assembly checkpoint's responsiveness. It is also involved in the degradation of CDC20.

ANAPC15 is also known as APC15, C11orf51, HSPC020.

Associated Diseases

• autosomal recessive nonsyndromic hearing loss 63
• endometrial cancer
• hearing loss, autosomal recessive
• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• homozygous familial hypercholesterolemia
• hypercholesterolemia, autosomal dominant, 3
• pancreatic triacylglycerol lipase deficiency
• hyperlipidemia due to hepatic triglyceride lipase deficiency
• hypercholesterolemia, autosomal dominant, type B