ANAPC11
Description
The ANAPC11 (anaphase promoting complex subunit 11) is a protein-coding gene located on chromosome 17.
Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene. ANAPC11 has been shown to interact with ANAPC2 and CDC27.
The ANAPC11 protein, along with ANAPC2, forms the catalytic core of the anaphase-promoting complex/cyclosome (APC/C), a crucial E3 ubiquitin ligase that regulates cell cycle progression during mitosis and the G1 phase. The APC/C controls this process by attaching ubiquitin tags to target proteins, leading to their degradation. Specifically, it primarily attaches 'Lys-11'-linked polyubiquitin chains, and to a lesser extent, 'Lys-48'- and 'Lys-63'-linked chains. ANAPC11 may also play a role in recruiting E2 ubiquitin-conjugating enzymes to the APC/C complex.
ANAPC11 is also known as APC11, Apc11p, HSPC214.
