AMER1 : APC membrane recruitment protein 1
Description
The AMER1 (APC membrane recruitment protein 1) is a protein-coding gene located on chromosome X.
The AMER1 gene provides instructions for making a protein found in tissues throughout the body. This protein helps regulate the Wnt signaling pathway, a series of chemical signals that affect how cells and tissues develop. Wnt signaling is vital for cell division, cell adhesion, cell migration, and many other cellular processes. The AMER1 protein can promote cell growth by activating the Wnt pathway or inhibit cell growth by repressing the Wnt pathway. When acting as a repressor, AMER1 acts as a tumor suppressor, helping to prevent cells from growing and dividing too rapidly or uncontrollably.
AMER1 acts as a regulator of the canonical Wnt signaling pathway. It binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and translocates to the cell membrane, where it interacts with key Wnt signaling regulators, including components of the beta-catenin destruction complex. AMER1 can act as both a positive and negative regulator of Wnt signaling, depending on the context. It promotes LRP6 phosphorylation, acting as a positive regulator. It also acts as a negative regulator by acting as a scaffold for the beta-catenin destruction complex, promoting Axin stabilization at the cell membrane and ultimately leading to CTNNB1 ubiquitination and degradation. AMER1 is involved in kidney development.
AMER1 is also known as FAM123B, OSCS, WTX.
